2021 United Soccer Coaches High School Regional Assistant Coaches of the Year
| REGION | NAME | SCHOOL, CITY AND STATE |
| Central | Joe Huppe | Bishop Miege High School, Roeland Park, Kan. |
| East | Nathan Greiner | Meridian High School, Falls Church, Va. |
| Mid-West | Alicia Elsenpeter | Gretna High School, Gretna, Neb. |
| North | Kevin May | Oregon High School, Oregon, Wis. |